Tipek（Ruminant）

What is Tipek (Ruminant)? 

Tipek (Ruminant) is a functional bioactive peptide product used as a cattle and sheep feed additive. Its core active ingredient is recombinant Epidermal Growth Factor (EGF), gene-engineered and produced via precision yeast fermentation — no animal-derived inputs, consistent biological activity, and no drug residue concerns.

The gastrointestinal tract is the largest mucosal immune organ in ruminants, serving as both the site of nutrient absorption and the first line of immune defense. EGF receptors (EGFR) are expressed throughout the ruminant gastrointestinal epithelium — from the rumen mucosa to the small intestine — and are activated by EGF to regulate epithelial cell proliferation, differentiation, and repair. Ruminants face gastrointestinal health challenges at every life stage: calves at weaning, beef cattle during intensification, and dairy cows in the periparturient period. Tipek directly addresses mucosal damage at the cellular level to restore absorptive function and support consistent production performance.

How Does Tipek (Ruminant) Work?

Recombinant EGF binds to EGFR on gastrointestinal epithelial cells, triggering autophosphorylation and activation of Ras/MAPK, PI3K/AKT, PLC-γ/PKC, and STATS signaling pathways — driving four measurable outcomes:

Promote Gastrointestinal Development

Directly regulates epithelial cell proliferation, differentiation, and migration throughout the gastrointestinal tract. Promotes intestinal tissue maturation and rumen mucosal development in calves. Supports longer intestinal length and higher villus density for greater absorptive
capacity.

Repair Mucosal Injury

Rapidly repairs gastrointestinal mucosal damage caused by pathogens, mycotoxins, transport stress, or feed transitions. Restores tight junction integrity to prevent leaky gut and secondary infection. EGF-mediated mucosal restitution is particularly effective following weaning stress, when the calf gastrointestinal tract adapts from liquid to solid feed and mucosal damage is common.

Strengthen Mucosal Immune Defense

Enhances structural integrity of the gastrointestinal mucosa. Reduces pathogenic microbial colonization and invasion. Strengthens mucosal immune function and non-specific immunity. Supports healthy rumen microbial diversity by maintaining mucosal barrier function.

Improve Feed Conversion

Promotes digestive enzyme secretion and nutrient transport carrier expression. Improves digestion and absorption efficiency for energy, protein, and minerals. Directly contributes to improved average daily gain, lower FCR, and better feed intake consistency under variable conditions.

What are the Benefits of Tipek（Ruminant)?

   For Calves
   (pre-weaning and post-weaning):

   For Beef Cattle:

   For Sheep and Lambs:

• Reduces bacterial and viral diarrhea during the  highest-risk period
• Promotes healthy rumen and intestinal development
• Reduces mortality risk from intestinal disease
• Supports healthy gut microbiome establishment
• Reduces antibiotic use in calf rearing programs

• Increases average daily gain
  (field trial: +0.23 kg/head/day)
• Improves final market weight
  (+17.85 kg/head over 50-day trial)
• Increases feed intake and feed conversion efficiency
• Reduces stress-induced gastrointestinal damage during transport and feed transitions
  

• Increases average daily gain
  (field trial: +42 g/head/day)
• Improves final weight
  (+1.3 kg/head over 30-day trial)
• Supports healthy gut microbiome development
  
  
  
  
  

Trial 2
Sheep Trial

Trial site: A 3,000-head sheep farm in Shandong Province
Trial period: October 14, 2024 – November 14, 2024 (30 days in total)
Breed: Small-tailed Han sheep
Age at trial: 60 to 90 days of age

TIPEK FAQ